Article

Quantifying evolutionary constraints on the intronic branch point sequence in the bovine and human genome

2021-03-28

Abstract excerpt

The branch point sequence is a cis-acting intronic motif required for mRNA splicing. Despite their functional importance, branch point sequences are not routinely annotated. Here we predict branch point sequences in 179,476 bovine introns and investigate their variability using a catalogue of 29.4 million variants detected in 266 cattle genomes. We localize the bovine branch point within a degenerate heptamer “nny...

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Literature Corpus work: 76e0223e-87f4-5c20-9b41-b91de41580f9
DOI: 10.1101/2021.03.26.437175

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