Article
Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2012
Kleiman Anna, Hübner Sabine, Rodriguez Parkitna Jan M, Neumann Anita, Hofer Stefan, Weigand Markus A, Bauer Michael, Schmid Wolfgang, Schütz Günter, Libert Claude, Reichardt Holger M, Tuckermann Jan P
Abstract excerpt
Sepsis is controlled by endogenous glucocorticoids (GCs). Previous studies provided evidence that crosstalk of the monomeric GC receptor (GR) with proinflammatory transcription factors is the crucial mechanism underlying the suppressive GC effect. Here we demonstrate that mice with a dimerization-deficient GR (GR(dim)) are highly susceptible to sepsis in 2 different models, namely cecal ligation and puncture and...
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