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Article

Mutant glucocorticoid receptor binding elements on the interleukin-6 promoter regulate dexamethasone effects.

BMC immunology - 26 Mar 2021

Chang Wen-Teng, Hong Ming-Yuan, Chen Chien-Liang, Hwang Chi-Yuan, Tsai Cheng-Chieh, Chuang Chia-Chang

Abstract excerpt

BACKGROUND: Glucocorticoids (GCs) have been extensively used as essential modulators in clinical infectious and inflammatory diseases. The GC receptor (GR) is a transcription factor belonging to the nuclear receptor family that regulates anti-inflammatory processes and releases pro-inflammatory cytokines, such as interleukin (IL)-6. RESULTS: Five putative GR binding sites and other transcriptional factor binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33771121
DOI: 10.1186/s12865-021-00413-z
PMCID: PMC7995394

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