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Article

Βeta 2-glycoprotein I protects mice against gram-negative septicaemia in a sexually dimorphic manner.

Scientific reports - 15 Aug 2017

El-Assaad Fatima, Qi Miao, Gordon Alice Kizny, Qi Jian, Dong Shangwen, Passam Freda, Weaver James Crofton, Giannakopoulos Bill, Krilis Steven Anthony

Abstract excerpt

The immune responses of males and females to bacterial infections display differences. The mechanisms that underlie this sexual dimorphism are multifactorial. Lipopolysaccharide (LPS) contributes to the pathogenesis of endotoxaemia. We have previously demonstrated that the plasma protein beta-2 glycoprotein-1 (β2GPI) reduces LPS-induced inflammation in male mice. In the present study using a more robust infection...

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Identifiers

PMID: 28811580
DOI: 10.1038/s41598-017-07945-8
PMCID: PMC5557990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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