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Article

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

10 May 2018

Abstract excerpt

TNF is an important mediator in numerous inflammatory diseases, e.g., in inflammatory bowel diseases (IBDs). In IBD, acute increases in TNF production can lead to disease flares. Glucocorticoids (GCs), which are steroids that bind and activate the glucocorticoid receptor (GR), are able to protect animals and humans against acute TNF-induced inflammatory symptoms. Mice with a poor transcriptional response of GR...

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PMID: 29746256
DOI: 10.1172/jci96636

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