Article
Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization.
PloS one - 1 Jan 2019
Van Looveren Kelly, Van Boxelaere Michiel, Callaerts-Vegh Zsuzsanna, Libert Claude
Abstract excerpt
Stress is a major risk factor for depression and anxiety. One of the effects of stress is the (over-) activation of the hypothalamic-pituitary-adrenal (HPA) axis and the release of stress hormones such as glucocorticoids (GCs). Chronically increased stress hormone levels have been shown to have detrimental effects on neuronal networks by inhibiting neurotrophic processes particularly in the hippocampus proper....
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