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Article

Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response.

The Journal of biological chemistry - 24 Jul 2009

Guo Ling, Song Zhiqing, Li Mengting, Wu Qingan, Wang Dan, Feng Hong, Bernard Philip, Daugherty Alan, Huang Bin, Li Xiang-An

Abstract excerpt

Sepsis is a leading cause of death that is characterized by uncontrolled inflammatory response. In this study, we report that scavenger receptor BI (SR-BI), a high density lipoprotein receptor, is a critical survival factor of sepsis. We induced sepsis using an established septic animal model, cecal ligation and puncture (CLP). CLP induced 100% fatality in SR-BI-null mice but only 21% fatality in wild type...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19491399
DOI: 10.1074/jbc.M109.020933
PMCID: PMC2740408

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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