Article
Disulphide linkage in mouse ST6Gal-I: determination of linkage positions and mutant analysis.
Journal of biochemistry - 1 Feb 2012
Hirano Yuichi, Suzuki Takehiro, Matsumoto Takumi, Ishihara Yoshimi, Takaki Yoshie, Kono Mari, Dohmae Naoshi, Tsuji Shuichi
Abstract excerpt
All cloned sialyltransferases from vertebrates are classified into four subfamilies and are characterized as having type II transmembrane topology. The catalytic domain has highly conserved motifs known as sialylmotifs. Besides sialylmotifs, each family has several unique conserved cysteine (Cys) residues mainly in the catalytic domain. The number and loci of conserved amino acids, however, differ with each...
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