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Article

Substitution of the N-glycan function in glycosyltransferases by specific amino acids: ST3Gal-V as a model enzyme.

Glycobiology - 1 Mar 2006

Uemura Satoshi, Kurose Takahiro, Suzuki Tomoko, Yoshida Sayaka, Ito Makoto, Saito Masaki, Horiuchi Masataka, Inagaki Fuyuhiko, Igarashi Yasuyuki, Inokuchi Jin-ichi

Abstract excerpt

The sialyltranferase ST3Gal-V transfers a sialic acid to lactosylceramide. We investigated the role of each of the N-glycans modifying mouse ST3Gal-V (mST3Gal-V) by measuring the in vitro enzyme activity of Chinese hamster ovary (CHO) cells transfected with ST3Gal-V cDNA or its mutants. By examining mutants of mST3Gal-V, in which each asparagine was replaced with glutamine (N180Q, N224Q, N334Q), we determined...

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Identifiers

PMID: 16306051
DOI: 10.1093/glycob/cwj060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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