Article
Identification of the role of a cysteine-rich region of PC6B by determining the enzymatic characteristics of its mutants.
Molecular biotechnology - 1 May 2004
Wang Lie, Yang Guanzhen, Wu Xiangfu
Abstract excerpt
In the proprotein convertases family, mouse PC6B (mPC6B) has a very large cysteine-rich region (CRR), consisting of 22 tandem cysteine-rich (Cys-rich) repeated segments. The role of this region remains elusive. In this report, to get insight on the possible role of the CRR, we constructed four truncated mPC6B mutant genes with 0, 5, 11, and 22 Cys-rich repeated segments remaining; using the baculovirus-expression...
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