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Article

Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity.

The Journal of biological chemistry - 14 Nov 2003

Yen Ten-Yang, Macher Bruce A, Bryson Steve, Chang Xiaoqing, Tvaroska Igor, Tse Roderick, Takeshita Sawako, Lew April M, Datti Alessandro

Abstract excerpt

Core 2 beta1,6-N-acetylglucosaminyltransferase I (C2GnT-I) plays a pivotal role in the biosynthesis of mucin-type O-glycans that serve as ligands in cell adhesion. To elucidate the three-dimensional structure of the enzyme for use in computer-aided design of therapeutically relevant enzyme inhibi...

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PMID: 12954635
DOI: 10.1074/jbc.M303851200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12954635-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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