Article
The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7α-hydroxyl sulfation of bile acids.
Bioscience, biotechnology, and biochemistry - 1 Aug 2018
Shimohira Takehiko, Kurogi Katsuhisa, Liu Ming-Cheh, Suiko Masahito, Sakakibara Yoichi
Abstract excerpt
Members of the cytosolic sulfotransferase (SULT) SULT2A subfamily are known to be critically involved in the homeostasis of steroids and bile acids. SULT2A8, a 7α-hydroxyl bile acid-preferring mouse SULT, has been identified as the major enzyme responsible for the mouse-specific 7-O-sulfation of bile acids. Interestingly, SULT2A8 lacks a conservative catalytic His residue at position 99th. The catalytic mechanism...
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