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Article

Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene.

Cancer discovery - 1 Aug 2011

Shen Chuan, Beroukhim Rameen, Schumacher Steven E, Zhou Jing, Chang Michelle, Signoretti Sabina, Kaelin William G

Abstract excerpt

UNLABELLED: Kidney cancers often delete chromosome 3p, spanning the VHL tumor suppressor gene, and chromosome 14q, which presumably harbors ≥ 1 tumor suppressor genes. pVHL inhibits the hypoxia-inducible transcription factor (HIF), and HIF2α is a kidney cancer oncoprotein. In this article, we identify focal, homozygous deletions of the HIF1α locus on 14q in clear cell renal carcinoma cell lines. Wild-type HIF1α...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, Pair 14

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

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Identifiers

PMID: 22037472
DOI: 10.1158/2159-8290.CD-11-0098
PMCID: PMC3202343

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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