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Article

Formation of Renal Cysts and Tumors in <i>Vhl/Trp53</i> -Deficient Mice Requires HIF1α and HIF2α

13 Jan 2016

Abstract excerpt

The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in the majority of clear cell renal cell carcinomas (ccRCC), but genetic ablation of Vhl alone in mouse models is insufficient to recapitulate human tumorigenesis. One function of pVHL is to regulate the stability of the hypoxia-inducible factors (HIF), which become constitutively activated in the absence of pVHL. In established ccRCC, HIF1α has...

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PMID: 26759234
DOI: 10.1158/0008-5472.can-15-1859

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