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Article

The role of HIF1α in renal cell carcinoma tumorigenesis.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2014

Gudas Lorraine J, Fu Leiping, Minton Denise R, Mongan Nigel P, Nanus David M

Abstract excerpt

UNLABELLED: The transcription factor HIF1α is implicated in the development of clear cell renal cell carcinoma (ccRCC). Although HIF1α was initially believed to be essential for ccRCC development, recent studies hypothesize an oncogenic role for HIF2α in ccRCC, but a tumor suppressor role for HIF1α, leading to uncertainty as to the precise roles of the different HIF transcription factors in this disease. Using...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

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Identifiers

PMID: 24916472
DOI: 10.1007/s00109-014-1180-z
PMCID: PMC4119538

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