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Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway

31 Mar 2022

Abstract excerpt

Inactivation of the VHL tumor suppressor gene is the signature initiating event in clear cell renal cell carcinoma (ccRCC), which is the most common form of kidney cancer. The VHL tumor suppressor protein marks hypoxia-inducible factor 1 (HIF1) and HIF2 for proteasomal degradation when oxygen is present. The inappropriate accumulation of HIF2 drives tumor formation by VHL tumor suppressor protein (pVHL)–defective...

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PMID: 35357972
DOI: 10.1073/pnas.2120403119

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