Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects.

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Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects.

Acta medica Okayama - 1 Oct 2011

Wang Lei, Kaku Haruki, Huang Peng, Xu Kexin, Yang Kai, Zhang Jiheng, Li Ming, Xie Liping, Wang Xiaofeng, Sakai Akiko, Watanabe Masami, Nasu Yasutomo, Shimizu Kenji, Kumon Hiromi, Na Yanqun

Abstract excerpt

Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients...

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PMID: 22037268

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