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Article

A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.

Breast cancer research and treatment - 1 Nov 2009

Wang Zhanwei, Xu Yan, Tang Jinhai, Ma Hongxia, Qin Jianwei, Lu Chen, Wang Xuechen, Hu Zhibin, Wang Xinru, Shen Hongbing

Abstract excerpt

RecQ helicases play a central role in maintaining genome stability and may interact with some important cancer-related proteins such as BRCA1. Mutations of the human RecQ helicase genes WRN and BLM lead to rare autosomal recessive disorders, Werner and Bloom syndromes, which are associated with p...

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Source

Identifiers

PMID: 19205873
DOI: 10.1007/s10549-009-0327-z

Genes

WRN
BLM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19205873-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.PMID 19205873Read ↗

Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer.Semantic proximity Read ↗

Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer.Semantic proximity Read ↗

Genetic variation in the premature aging gene WRN: a case-control study on breast cancer susceptibility.Semantic proximity Read ↗

Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects.Semantic proximity Read ↗

Association Between WRN Cys1367Arg (T>C) and Cancer Risk: A Meta-analysis.Semantic proximity Read ↗

Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.Semantic proximity Read ↗

Analysis of DNA Repair Genes Polymorphisms in Breast Cancer.Semantic proximity Read ↗

Mutations in conserved functional domains of human RecQ helicases are associated with diseases and cancer: A review.Semantic proximity Read ↗

Germline RECQL mutations in high risk Chinese breast cancer patients.Semantic proximity Read ↗

Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases.Semantic proximity Read ↗

The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C.Semantic proximity Read ↗

WRN Cys1367Arg SNP is not associated with risk and prognosis of gliomas in Southeast Brazil.Semantic proximity Read ↗

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