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Article

Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population.

Age (Dordrecht, Netherlands) - 1 Dec 2013

Jiang Shengqun, Hu Nan, Zhou Jing, Zhang Junfang, Gao Ruifang, Hu Jianyan, Guan Huaijin

Abstract excerpt

Werner syndrome is caused by mutations in the DNA repair Werner helicase (WRN) gene and characterized by accelerated aging including cataracts. Age-related cataract (ARC) cases (N = 504) and controls (N = 244) were recruited from a population-based study to evaluate the association of single-nucleotide polymorphisms (SNPs) of WRN and another DNA repair gene (human 8-oxoguanine DNA N-glycosylase 1) with ARC. Among...

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Identifiers

PMID: 23334603
DOI: 10.1007/s11357-013-9512-4
PMCID: PMC3824989

Genes

ARC
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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