Article
Heterogeneous leukemic clones identified by NPM1 mutation analysis in patient with acute monocytic leukemia.
Leukemia & lymphoma - 1 May 2012
Qiao Chun, Zhang Run, Hong Ming, Wang Li, Zhang Jian-Fu, Wu Yu-Jie, Qiu Hai-Rong, Qiu Hong-Xia, Qian Si-Xuan, Lu Hua, Zhang Su-Jiang, Li Jian-Yong
Abstract excerpt
NPM1 mutation is the most common molecular abnormality in patients with acute myeloid leukemia (AML), especially normal karyotype AML (NK-AML), and is associated with a favorable prognosis in the absence of concomitant FLT3-ITD. Like other molecular abnormalities such as FLT3-ITD, C/EBPα and c-Kit mutation, NPM1 mutation normally presents as a recurrent molecular abnormality. The NPM1 mutation is generally used...
Topics
- Clone Cells
- Humans
- Leukemia, Monocytic, Acute
- Male
- Mutant Proteins
- Mutation
- Nuclear Proteins
- Nucleophosmin
- Remission Induction