Prognostic impact of immunophenotypic classification for newly diagnosed NPM1-mutated acute myeloid leukemia.

doi:10.1002/cyto.b.70016

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Article

Prognostic impact of immunophenotypic classification for newly diagnosed NPM1-mutated acute myeloid leukemia.

Cytometry. Part B, Clinical cytometry - 1 Mar 2026

Martín-Herreros Beatriz, Cordón Lourdes, Sargas Claudia, Romero Samuel, Linares María Dolores, Lloret Pilar, Navarro-Vicente Irene, Cano Isabel, Acuña-Cruz Evelyn, Torres-Miñana Laura, Rodríguez-Veiga Rebeca, Martínez-Cuadron David, Boluda Blanca, Barragán Eva, Sempere Amparo, Montesinos Pau

Abstract excerpt

NPM1 mutations are among the most frequent genetic alterations in acute myeloid leukemia (AML) and have been associated with several immunophenotypic features. This study aims to characterize the immunophenotypic profile of this entity at diagnosis using multiparametric flow cytometry and to evaluate the impact of phenotype classifications on prognosis. Immunophenotypic analysis enabled the identification and...

Topics

Humans
Nucleophosmin
Immunophenotyping
Leukemia, Myeloid, Acute
Nuclear Proteins
Female
Flow Cytometry
Mutation
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Adult

Aged

Male

Adolescent

Aged, 80 and over

Young Adult

Neutrophils

HLA-DR Antigens

Source

Open in PubMed

Identifiers

PMID: 41689290
DOI: 10.1002/cyto.b.70016

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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