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Targeted therapy in NPM1-mutated AML: Knowns and unknowns

27 Sept 2022

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by malignant proliferation of myeloid hematopoietic stem/progenitor cells. NPM1 represents the most frequently mutated gene in AML and approximately 30% of AML cases carry NPM1 mutations. Mutated NPM1 result in the cytoplasmic localization of NPM1 (NPM1c). NPM1c interacts with other proteins to block myeloid differentiation, promote cell...

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PMID: 36237321
DOI: 10.3389/fonc.2022.972606

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