Functional defect caused by the 4544G>A SNP in ABCC2:  potential impact for drug cellular disposition.

doi:10.1097/FPC.0b013e32834d672b

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Article

Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition.

Pharmacogenetics and genomics - 1 Dec 2011

Elens Laure, Tyteca Donatienne, Panin Nadtha, Courtoy Pierre, Lison Dominique, Demoulin Jean-Baptiste, Haufroid Vincent

Abstract excerpt

OBJECTIVES: ABCC2 contributes to the active cellular efflux of several endogenous and exogenous compounds. The 4544G>A (rs8187710) single nucleotide polymorphism (SNP), which is coding for a C1515Y substitution, has been previously associated with susceptibility to cholestatic liver disease, doxorubicin cardiotoxicity, nonalcoholic fatty liver disease, decreased graft function after renal transplantation and...

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PMID: 22027652
DOI: 10.1097/FPC.0b013e32834d672b

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ABCC2

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