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Article

Single nucleotide polymorphisms modify the transporter activity of ABCG2.

Cancer chemotherapy and pharmacology - 1 Aug 2005

Morisaki Kuniaki, Robey Robert W, Ozvegy-Laczka Csilla, Honjo Yasumasa, Polgar Orsolya, Steadman Kenneth, Sarkadi Balázs, Bates Susan E

Abstract excerpt

Single nucleotide polymorphism (SNP) analyses of the ABCG2 gene have revealed three nonsynonymous SNPs resulting in the amino acid changes at V12M, Q141K and D620N. To determine whether the SNPs have an effect on drug transport, human embryonic kidney cells (HEK-293) were stably transfected with full length ABCG2 coding wild-type or SNP variants of ABCG2. In 4-day cytotoxicity assays with mitoxantrone, topotecan,...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15838659
DOI: 10.1007/s00280-004-0931-x

Genes

ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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