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Article

Single-nucleotide polymorphisms of ABCG2 increase the efficacy of tyrosine kinase inhibitors in the K562 chronic myeloid leukemia cell line.

Pharmacogenetics and genomics - 1 Jan 2014

Skoglund Karin, Boiso Moreno Samuel, Jönsson Jan-Ingvar, Vikingsson Svante, Carlsson Björn, Gréen Henrik

Abstract excerpt

OBJECTIVE: The tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukemia are substrates for the efflux transport protein ATP-binding cassette subfamily G member 2 (ABCG2). Variations in ABCG2 activity might influence pharmacokinetics and therapeutic outcome of TKIs. The role of ABCG2 single-nucleotide polymorphisms (SNPs) in TKI treatment is not clear and functional in-vitro studies are...

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Identifiers

PMID: 24322003
DOI: 10.1097/FPC.0000000000000022

Genes

ABCG2

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