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Article

In vitro identification of decreased function phenotype ABCG2 variants.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 1 Sept 2023

Suominen Laura, Sjöstedt Noora, Vellonen Kati-Sisko, Gynther Mikko, Auriola Seppo, Kidron Heidi

Abstract excerpt

Reduced activity of efflux transporter ABCG2, caused e.g., by inhibition or decreased function genetic variants, can increase drug absorption and plasma levels. ABCG2 has one clinically significant single nucleotide variant Q141K (c.421C>A), which leads to decreased protein levels and transport activity. In addition to Q141K, ABCG2 has over 500 rare (<1% minor allele frequency) nonsynonymous variants, but their...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37451410
DOI: 10.1016/j.ejps.2023.106527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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