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Article

Genetic polymorphisms of xenobiotic-metabolizing enzymes influence the risk of pulmonary emphysema.

Pharmacogenetics and genomics - 1 Dec 2011

Kukkonen Mari K, Hämäläinen Satu, Kaleva Simo, Vehmas Tapio, Huuskonen Matti S, Oksa Panu, Vainio Harri, Piirilä Päivi, Hirvonen Ari

Abstract excerpt

BACKGROUND: Pulmonary emphysema is a smoking-induced condition of the lung. Genetically determined differences in the activities of enzymes that metabolize oxidative agents are suspected to modify individual susceptibility to emphysema, as well as other smoking-related pulmonary disorders. OBJECTIVES: We investigated whether polymorphisms in selected xenobiotic-metabolizing enzyme genes predispose to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22027651
DOI: 10.1097/FPC.0b013e32834d597f

Genes

GSTT1
EPHX1
GSTM3
GSTM1
GSTP1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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