Article
Genes, oxidative stress, and the risk of chronic obstructive pulmonary disease.
Thorax - 1 Aug 1998
Koyama H, Geddes D M
Abstract excerpt
BACKGROUND: The first-pass metabolism of foreign compounds in the lung is an important protective mechanism against oxidative stress. We investigated whether polymorphisms in the gene for microsomal epoxide hydrolase (mEPHX), an enzyme involved in this protective process, had any bearing on individual susceptibility to the development of chronic obstructive pulmonary disease (COPD) and emphysema. METHODS: We...
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