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Article

Genetic susceptibility to asbestos-related fibrotic pleuropulmonary changes.

The European respiratory journal - 1 Sept 2011

Kukkonen M K, Hämäläinen S, Kaleva S, Vehmas T, Huuskonen M S, Oksa P, Vainio H, Piirilä P, Hirvonen A

Abstract excerpt

The objective of this study was to determine whether genetic polymorphisms in enzymes that metabolise oxidative agents modify the individual susceptibility to developing asbestos and smoking-related pleuropulmonary changes. Nine polymorphisms of six genes (EPHX1, GSTM1, GSTM3, GSTP1, GSTT1 and NAT2) were genotyped from 1,008 Finnish asbestos-exposed workers. The genotype data were compared to signs of lung...

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Source

Identifiers

PMID: 20847076
DOI: 10.1183/09031936.00049810

Genes

GSTM1
GSTT1
EPHX1
GSTM3
GSTP1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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