Article
Combined analysis of EPHX1, GSTP1, GSTM1 and GSTT1 gene polymorphisms in relation to chronic obstructive pulmonary disease risk and lung function impairment.
Disease markers - 1 Jan 2011
Lakhdar Ramzi, Denden Sabri, Knani Jalel, Leban Nadia, Daimi Houria, Hassine Mohsen, Lefranc Gérard, Chibani Jemni Ben, Khelil Amel Haj
Abstract excerpt
Smoking is considered as the major causal factor of chronic obstructive pulmonary disease (COPD). Nevertheless, a minority of chronic heavy cigarette smokers develops COPD. This suggests important contribution of other factors such as genetic predisposing. Our objective was to investigate combined role of EPHX1, GSTP1, M1 and T1 gene polymorphisms in COPD risk, its phenotypes and lung function impairment....
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