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Article

The human epidermal growth factor receptor (EGFR) gene in European patients with advanced colorectal cancer harbors infrequent mutations in its tyrosine kinase domain.

BMC medical genetics - 25 Oct 2011

Metzger Brigitte, Chambeau Laetitia, Begon Dominique Y, Faber Carlo, Kayser Jacques, Berchem Guy, Pauly Marc, Boniver Jacques, Delvenne Philippe, Dicato Mario, Wenner Thomas

Abstract excerpt

BACKGROUND: The epidermal growth factor receptor (EGFR), a member of the ErbB family of receptors, is a transmembrane tyrosine kinase (TK) activated by the binding of extracellular ligands of the EGF-family and involved in triggering the MAPK signaling pathway, which leads to cell proliferation. Mutations in the EGFR tyrosine kinase domain are frequent in non-small-cell lung cancer (NSCLC). However, to date, only...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22026926
DOI: 10.1186/1471-2350-12-144
PMCID: PMC3215960

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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