Article
The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers.
Journal of surgical oncology - 1 Jan 2006
Mimori Koshi, Nagahara Hisashi, Sudo Tomoya, Ishii Hideshi, Yamashita Keishi, Barnard Graham F, Mori Masaki
Abstract excerpt
BACKGROUND AND OBJECTIVES: Recent studies have disclosed the presence of somatic mutations in the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers (NSCLC), and susceptibility to the EGFR tyrosine kinase inhibitor (gefitinib) was determined by the presence of mutations in the kinase domain of this gene. We thus predicted a clinical benefit of gefitinib against the 12% of primary...
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