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Article

The - 216G/T polymorphism in the EGFR gene: A review focusing on Non-Small lung cancer.

Molecular biology reports - 10 Dec 2025

Obradovic Jasmina, Jurisic Vladimir

Abstract excerpt

The epidermal growth factor receptor (EGFR) is a key regulator of cell proliferation and a well-established therapeutic target in non-small-cell lung cancer (NSCLC). Somatic mutations in the EGFR gene have been widely studied in the context of tyrosine kinase inhibitors (TKIs), but germline polymorphisms as potentially predictive biomarkers have emerged as a variants of interest over the years. Among these, the...

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Identifiers

PMID: 41369839
DOI: 10.1007/s11033-025-11242-3

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EGFR

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