Article
EGFR gene alterations in a Norwegian cohort of lung cancer patients selected for surgery.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2011
Helland Åslaug, Skaug Hege Marian, Kleinberg Lilach, Iversen Marius Lund, Rud Ane Kongsgaard, Fleischer Thomas, Sagerup Camilla, Solberg Steinar, Jørgensen Lars, Ariansen Sarah, Brustugun Odd Terje
Abstract excerpt
INTRODUCTION: Lung cancer is the leading cause of cancer-related deaths worldwide. New therapies targeting the epidermal growth factor receptor (EGFR) tyrosine kinase are promising and show high response rates in the subset of patients with activating mutations in EGFR. The frequency of these mutations is largely unknown in unselected Caucasian patients. METHODS: Mutation analysis of EGFR exons 18-21 was...
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