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Epidermal growth factor receptor exon 20 insertion variants in non-small cell lung cancer patients.

Critical reviews in oncology/hematology - 1 Jan 2022

Malapelle Umberto, Pilotto Sara, Reale Maria Lucia, Passiglia Francesco, Pisapia Pasquale, Pepe Francesco, Belluomini Lorenzo, Galetta Domenico, Cortinovis Diego, Tiseo Marcello, Passaro Antonio, Seminati Davide, Pagni Fabio, Parra Hector Soto, Migliorino Maria Rita, Rocco Danilo, Troncone Giancarlo, Novello Silvia

Abstract excerpt

Epidermal growth factor receptor (EGFR) exon 20 insertions occur rarely among different cancer types, with the highest frequency reported among non-small-cell lung cancer (NSCLC) patients, particularly adenocarcinomas (ADCs). Exon 20 insertions fall back in the tyrosine kinase domain, and can be clustered into two principal groups represented by in frame insertions and three to 21 bp (corresponding to 1-7 amino...

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PMID: 34801697
DOI: 10.1016/j.critrevonc.2021.103536

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