Article
Somatic mutations of the tyrosine kinase domain of epidermal growth factor receptor and tyrosine kinase inhibitor response to TKIs in non-small cell lung cancer: an analytical database.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Aug 2008
Murray Samuel, Dahabreh Issa J, Linardou Helena, Manoloukos Menelaos, Bafaloukos Dimitrios, Kosmidis Paris
Abstract excerpt
BACKGROUND: After the discovery of somatic mutations in the tyrosine kinase domain (exons 18-24) of the epidermal growth factor receptor (EGFR) correlating with responses of non-small cell lung cancer (NSCLC) to the tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib, there has been increasing interest in utilizing this molecular marker for treatment selection. We aimed to analytically catalogue the...
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