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Article

Somatic mutations of epidermal growth factor receptor in colorectal carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2005

Nagahara Hisashi, Mimori Koshi, Ohta Mitsuhiko, Utsunomiya Tohru, Inoue Hiroshi, Barnard Graham F, Ohira Masaichi, Hirakawa Kosei, Mori Masaki

Abstract excerpt

PURPOSE: Somatic mutations of the epidermal growth factor receptor (EGFR) gene may predict the sensitivity of non-small cell lung carcinoma to gefitinib. However, no mutations have been reported for colorectal carcinoma. We therefore analyzed EGFR mutations in colorectal adenocarcinomas by the combined use of laser microdissection and sequencing of genomic DNA. EXPERIMENTAL DESIGN: We examined 11 representative...

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PMID: 15746034
DOI: 10.1158/1078-0432.CCR-04-1894

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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