Article
Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2005
Thomas R K, Greulich H, Yuza Y, Lee J C, Tengs T, Feng W, Chen T-H, Nickerson E, Simons J, Egholm M, Rothberg J M, Sellers W R, Meyerson M L
Abstract excerpt
The complete sequencing of the human genome and the development of molecularly targeted cancer therapy have promoted efforts to identify systematically the genetic alterations in human cancer. By high-throughput sequencing of tyrosine kinase genes in human non-small-cell lung cancer, we identified somatic mutations in the kinase domain of the epidermal growth factor receptor tyrosine kinase gene (EGFR) that are...
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