Article

Cellular Interplay and Cytokine Hierarchy Cause Pathological Cardiac Hypertrophy in <i>RAF1</i> -Mutant Noonan Syndrome

2017-03-30

Abstract excerpt

Noonan syndrome (NS) is caused by mutations in RAS/ERK pathway genes, and is characterized by craniofacial, growth, cognitive and cardiac defects. NS patients with kinase-activating RAF1 alleles typically develop pathological left ventricular hypertrophy (LVH), which is reproduced in Raf1 L613V/+ knock-in mice. Here, using inducible Raf1 L613V expression, we show that LVH results from the interplay of cardiac...

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Literature Corpus work: 7c92c847-5a57-5cb1-ba9f-c4dd6bde574a
DOI: 10.1101/122150

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