Article
Indoleamides are active against drug-resistant Mycobacterium tuberculosis.
Nature communications - 1 Jan 2013
Lun Shichun, Guo Haidan, Onajole Oluseye K, Pieroni Marco, Gunosewoyo Hendra, Chen Gang, Tipparaju Suresh K, Ammerman Nicole C, Kozikowski Alan P, Bishai William R
Abstract excerpt
Responsible for nearly two million deaths each year, the infectious disease tuberculosis remains a serious global health challenge. The emergence of multidrug- and extensively drug-resistant strains of Mycobacterium tuberculosis confounds control efforts, and new drugs with novel molecular targets are desperately needed. Here we describe lead compounds, the indoleamides, with potent activity against both...
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