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Article

Thienopyrimidine amide analogs target MmpL3 in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 5 Nov 2025

Baldin Vanessa Pietrowski, Harding Christopher L, Quach Diana, Sugie Joseph, Pogliano Joe, Parish Tanya

Abstract excerpt

The identification of novel agents with mechanisms of action distinct from those currently utilized in tuberculosis treatment remains a significant challenge. The mycobacterial protein MmpL3 has emerged as a promising drug target due to its essential role in the synthesis of the cell wall of Mycobacterium tuberculosis. We previously identified novel thienopyrimidine amides(TPAs) with good anti-tubercular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40980915
DOI: 10.1128/aac.00980-25
PMCID: PMC12587563

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