Article
Active Benzimidazole Derivatives Targeting the MmpL3 Transporter in Mycobacterium abscessus.
ACS infectious diseases - 14 Feb 2020
Raynaud Clément, Daher Wassim, Johansen Matt D, Roquet-Banères Françoise, Blaise Mickael, Onajole Oluseye K, Kozikowski Alan P, Herrmann Jean-Louis, Dziadek Jaroslaw, Gobis Katarzyna, Kremer Laurent
Abstract excerpt
The prevalence of pulmonary infections due to nontuberculous mycobacteria such as Mycobacterium abscessus has been increasing and surpassing tuberculosis (TB) in some industrialized countries. Because of intrinsic resistance to most antibiotics that drastically limits conventional chemotherapeutic treatment options, new anti-M. abscessus therapeutics are urgently needed against this emerging pathogen. Extensive...
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