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Article

The molecular signature underlying the thymic migration and maturation of TCRαβ+ CD4+ CD8 thymocytes.

PloS one - 1 Jan 2011

Teng Fei, Zhou Yubin, Jin Rong, Chen Yu, Pei Xiaoyan, Liu Yuanfeng, Dong Jie, Wang Wei, Pang Xuewen, Qian Xiaoping, Chen Wei-Feng, Zhang Yu, Ge Qing

Abstract excerpt

BACKGROUND: After positive selection, the newly generated single positive (SP) thymocytes migrate to the thymic medulla, where they undergo negative selection to eliminate autoreactive T cells and functional maturation to acquire immune competence and egress capability. METHODOLOGY/PRINCIPAL FINDINGS: To elucidate the genetic program underlying this process, we analyzed changes in gene expression in four subsets...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

Open in PubMed Open full text

Identifiers

PMID: 22022412
DOI: 10.1371/journal.pone.0025567
PMCID: PMC3192722

Genes

CCR7
KLF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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