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Article

CD8αα intraepithelial lymphocytes arise from two main thymic precursors.

Nature immunology - 1 Jul 2017

Ruscher Roland, Kummer Rebecca L, Lee You Jeong, Jameson Stephen C, Hogquist Kristin A

Abstract excerpt

TCRαβ+CD4-CD8α+CD8β- intestinal intraepithelial lymphocytes (CD8αα IELs) are an abundant population of thymus-derived T cells that protect the gut barrier surface. We sought to better define the thymic IEL precursor (IELp) through analysis of its maturation, localization and emigration. We defined two precursor populations among TCRβ+CD4-CD8- thymocytes by dependence on the kinase TAK1 and rigorous...

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Identifiers

PMID: 28530714
DOI: 10.1038/ni.3751
PMCID: PMC5505317

Genes

CXCR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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