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Article

Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells.

Genetics - 1 Aug 2020

Tracy Maxwell A, Lee Mitchell B, Hearn Brady L, Dowsett Ian T, Thurber Luke C, Loo Jason, Loeb Anisha M, Preston Kent, Tuncel Miles I, Ghodsian Niloufar, Bode Anna, Tang Thao T, Chia Andy R, Herr Alan J

Abstract excerpt

Mutations affecting DNA polymerase exonuclease domains or mismatch repair (MMR) generate "mutator" phenotypes capable of driving tumorigenesis. Cancers with both defects exhibit an explosive increase in mutation burden that appears to reach a threshold, consistent with selection acting against further mutation accumulation. In Saccharomyces cerevisiae haploid yeast, simultaneous defects in polymerase proofreading...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32513814
DOI: 10.1534/genetics.120.303333
PMCID: PMC7404223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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