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Article

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.

Molecular and cellular biology - 1 Oct 2004

Du Xiaobing, Shen Johnny, Kugan Nishan, Furth Emma E, Lombard David B, Cheung Catherine, Pak Sally, Luo Guangbin, Pignolo Robert J, DePinho Ronald A, Guarente Leonard, Johnson F Brad

Abstract excerpt

The Werner and Bloom syndromes are caused by loss-of-function mutations in WRN and BLM, respectively, which encode the RecQ family DNA helicases WRN and BLM, respectively. Persons with Werner syndrome displays premature aging of the skin, vasculature, reproductive system, and bone, and those with...

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Source

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Identifiers

PMID: 15367665
DOI: 10.1128/MCB.24.19.8437-8446.2004
PMCID: PMC516757

Genes

BLM
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15367665-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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