Article
AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors.
Blood - 15 Dec 2011
Nakagawa Masahiro, Shimabe Munetake, Watanabe-Okochi Naoko, Arai Shunya, Yoshimi Akihide, Shinohara Akihito, Nishimoto Nahoko, Kataoka Keisuke, Sato Tomohiko, Kumano Keiki, Nannya Yasuhito, Ichikawa Motoshi, Imai Yoichi, Kurokawa Mineo
Abstract excerpt
Functional deregulation of transcription factors has been found in many types of tumors. Transcription factor AML1/RUNX1 is one of the most frequent targets of chromosomal abnormalities in human leukemia and altered function of AML1 is closely associated with malignant transformation of hematopoietic cells. However, the molecular basis and therapeutic targets of AML1-related leukemia are still elusive. Here, we...
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