Constitutive NF-κB activation in AML: Causes and treatment strategies.

Abstract excerpt

For more than a decade, it has been known that NF-κB is constitutively activated in a majority of acute myeloid leukemia (AML) patients which contributes to the resistance to apoptosis. Inhibition of NF-κB has been shown to induce apoptosis in AML cells, but the clinical effectiveness of NF-κB inhibitors has been inadequate. In recent years, possible causes underlying this continuous NF-κB activity have been...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Hematopoiesis
• Share to Leukemia, Myeloid, Acute