Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deregulated Gene Expression Profiles and Regulatory Networks in Adult and Pediatric RUNX1/RUNX1T1-Positive AML Patients

16 Mar 2023

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous and complex disease concerning molecular aberrations and prognosis. RUNX1/RUNX1T1 is a fusion oncogene that results from the chromosomal translocation t(8;21) and plays a crucial role in AML. However, its impact on the transcriptomic profile of different age groups of AML patients is not completely understood. Here, we investigated the deregulated gene expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Histone Deacetylase Inhibitors Research
Share to Multiple Myeloma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36980682
DOI: 10.3390/cancers15061795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deregulated Gene Expression Profiles and Regulatory Networks in Adult and Pediatric RUNX1/RUNX1T1-Positive AML PatientsPMID 36980682Read ↗

Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemiaSemantic proximity Read ↗

Dissecting the transcriptional regulation of infant and childhood acute myeloid leukemiaSemantic proximity Read ↗

Integrative analysis of RUNX1 downstream pathways and target genes.Semantic proximity Read ↗

Identification of Novel Genes Implicated in Acute Myeloid Leukemia Progression using Bioinformatics Analysis of Microarray DataSemantic proximity Read ↗

Transcriptional networks in acute myeloid leukemiaSemantic proximity Read ↗

Distinct gene expression pattern of RUNX1 mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia.Semantic proximity Read ↗

MicroRNA-363-3p promote the development of acute myeloid leukemia with RUNX1 mutation by targeting SPRYD4 and FNDC3B.Semantic proximity Read ↗

RUNX1 and cancerSemantic proximity Read ↗

PLA2G4A Is a Potential Biomarker Predicting Shorter Overall Survival in Patients with Non-M3/ NPM1 Wildtype Acute Myeloid LeukemiaSemantic proximity Read ↗

The Leukemia-Specific Fusion Gene ETV6/RUNX1 Perturbs Distinct Key Biological Functions Primarily by Gene RepressionSemantic proximity Read ↗

The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies.Semantic proximity Read ↗

Comprehensive Gene Expression Analysis Reveals Factors that Influence the Progression, Occurrence and Development of AML-M4Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.