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Article

Dysregulated MAPK signaling pathway in acute myeloid leukemia with RUNX1 mutations.

Expert review of hematology - 1 Aug 2022

He Mingmin, Jia Yongqin, Wang Yan, Cai Xiongwei

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is a hematologic malignancy with genetic alterations. RUNX1, which is an essential transcription factor for hematopoiesis, is frequently mutated in AML. Loss-of-function mutation of RUNX1 is correlated with poor prognosis of AML patients. It is urgent to reveal the underlying mechanism. RESEARCH DESIGN AND METHODS: TCGA AML, GSE106291, GSE142700, and GSE67609 datasets were...

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PMID: 35902358
DOI: 10.1080/17474086.2022.2108015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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